Oggi 2 Febbraio 2015 ore 10.00 Aula robotica della nostra International School of Robotics in Grosseto ITA :il fervore delle grandi occasioni,chirurghi da tutta la Toscana,è attesa una lettura magistrale da parte di YW Kim massimo esperto di chirurgia gastrica mininvasiva ,giunto ieri da Seul.E’disinvolto,gentile ed affabile come lo sono molti asiatici,ma si percepisce un carattere determinato come attestato dalle 5000 procedure gastriche del suo curriculum.Una cifra da urlo.E l’incontro non tradisce le attese!
Emerging Role of Robot-assisted Gastrectomy: Analysis of Consecutive 200 Cases
Ji Yeon Park,1 Young-Woo Kim,corresponding author1 Keun Won Ryu,1 Bang Wool Eom,1 Hong Man Yoon,1 and Daniel Reim1,2
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Robotic surgery for gastric cancer is a promising alternative to laparoscopic surgery, but the data are limited. We aimed to evaluate whether gaining experience in robotic gastrectomy could improve surgical outcomes in the treatment of gastric cancer.
Materials and Methods
Two hundred and seven consecutive cases of patients with clinical stage I gastric cancer who underwent robotic surgery at the National Cancer Center of Korea between February 2009 and February 2012 were retrospectively reviewed. Surgical outcomes were analyzed and compared between the initial 100 and later 100 cases.
Seven patients required conversion to open surgery and were excluded from further analysis. The mean operating time for all patients was 248.8 minutes, and mean length of hospitalization was 8.0 days. Twenty patients developed postoperative complications. Thirteen were managed conservatively, while 6 had major complications requiring invasive procedures. One mortality occurred owing to myocardial infarction. Operating time was significantly shorter in the latter 100 cases than in the initial 100 cases (269.9 versus 233.5 minutes, P<0.001). The number of retrieved lymph nodes was significantly greater in the latter cases (35.9 versus 39.9, P=0.032). The hospital stay of patients with complications was significantly longer in the initial cases than in the latter cases (16 versus 7 days, P=0.005).
Increased experience with the robotic procedure for gastric cancer was associated with improved outcomes, especially in operating time, lymph node retrieval, and shortened hospital stay of complicated patients. Further development of surgical techniques and technology might enhance the role of robotic surgery for gastric cancer.
Keywords: Stomach neoplasms, Minimally invasive surgical procedures, Robotics, Laparoscopy
Robotic technology is one of the latest developments in minimally invasive surgery. Adoption of robotic surgery has come into the spotlight in various fields of surgery as a solution to the shortcomings of conventional laparoscopic surgery and is expected to play a role in advanced laparoscopic surgery. A robotic system was first applied to gastric cancer surgery in 1997, but reports on robotic gastrectomy are sparse owing to its slow adoption in many countries. After Song et al.1 reported on a large series of robotic surgeries for gastric cancer in 2005, the procedure gradually increased in popularity among several tertiary hospitals in Korea.
The most important clinical question regarding use of a robotic system vs. conventional open or laparoscopic surgery for gastric cancer is whether there is an objective benefit to compensate for its high expense. Laparoscopic gastrectomy has long been promoted for feasibility and efficacy for gastric cancer2-4 and ultimately has proven to be superior to open surgery in terms of postoperative quality of life, shortened hospital stay, and improved postoperative pain.5 Several studies have demonstrated that robotic gastrectomy is comparable to laparoscopic gastrectomy in terms of feasibility and safety, but few have shown a definite benefit of robotics over the laparoscopic approach, and most studies included their initial learning experience in the analysis.1,6-8 It would be easy to justify adopting robotic gastrectomy, in spite of its high cost, if there were any specific value. Considering the time it takes to master the standard operative technique with newly adopted instruments, an unbiased assessment of robotic gastrectomy after the initial learning experience is necessary.
This study investigated 200 consecutive cases of robotic gastrectomy in a single institution and compared the surgical outcomes between the initial 100 and later 100 cases. We aimed to evaluate the improvement in surgical outcomes associated with the learning experience of robot-assisted gastrectomy and to investigate the possible benefit of robotic assistance in gastric cancer surgery after sufficient experience.
Materials and Methods
1. Study design and inclusion criteria
A robotic system was first used for gastric cancer surgery at the National Cancer Center of Korea in February 2009. Between February 2009 and February 2012, 207 consecutive patients who were clinically diagnosed with stage I gastric cancer according to the American Joint Committee on Cancer (AJCC) 7th edition and underwent robot-assisted gastrectomy were enrolled in a retrospective analysis. Clinical diagnosis was obtained by esophagogastroduodenoscopy, endoscopic ultrasonography, and computed tomography. The prospectively established database and medical records of these patients were retrospectively reviewed.
2. Operative procedures
The da Vinci® Surgical System (Intuitive Surgical Inc., Sunnyvale, CA, USA) was used for all robotic procedures. The procedures were performed by 3 surgeons who were all highly experienced in conventional laparoscopic gastrectomy. These surgeons all completed at least 200 laparoscopic gastrectomies prior to performing robotic surgery. The operation was performed according to the institutionally standardized operative rules: (1) partial omentectomy, (2) resection margin more than 2 cm from the primary tumor, and (3) D1+ or more lymphadenectomy based on Japanese Research Society for Gastric Cancer guidelines.
Patients were placed under general anesthesia and positioned in reverse Trendelenburg with slight leg elevation. The camera port was inserted through the umbilicus with a 12-mm trocar after establishing the pneumoperitoneum through a Veress needle. Three additional trocars (8 mm in diameter) for robotic arms were placed under camera visualization, and 1 assistant port was placed in the left umbilical level port using a 12-mm trocar. After docking the robotic arms with a surgical cart placed above the patient’s head, a modified liver lift was performed, enabling full exposure of the operative field by transfixing the left lateral segment of the liver to the abdominal wall with a straight needle. Four robotic arms were used during the operation: a central one for a dual-channel endoscope, and the others for Cadiere forceps, bipolar Maryland forceps, and unipolar electrocautery or ultrasonic shears, depending on the surgeon’s preference. The procedure itself was similar to conventional laparoscopic procedures described previously.8,9 After dissection and full mobilization of the stomach, the robotic arms were undocked from the patient. All anastomoses were performed extracorporeally via a 4 to 6 cm mini-laparotomy incision in the epigastrium.
3. Surgical and oncologic outcomes
Electronic medical records and prospectively collected data from the Gastric Cancer Center database were reviewed for surgical outcomes. Intraoperative parameters such as operating time and blood loss were assessed. Operating time was defined as time from skin incision to wound closure. Postoperative complications were graded according to the Accordion Severity Grading System.10 Pathologic results were also reviewed in terms of Lauren’s classification, histology, tumor location, size, and resection margin. Final pathologic stage was assessed according to the AJCC 7th edition.11
Statistical analysis was performed using the SAS program (SAS Institute Inc., Cary, NC, USA). Means and standard deviations were calculated. The chi-square test or Fisher’s exact test was applied to analyze categorical variables, and the Student’s t-test was used for continuous variables. Linear regression was applied to evaluate change in operating time according to the accumulated cases. A P-value less than 0.05 was considered statistically significant.
1. Patient characteristics and their surgical outcomes
Seven patients required conversion to open surgery due to severe adhesion, bleeding during operation, or inadequate resection margin, and these patients were excluded from further analysis. The demographics of the 200 enrolled patients are shown in Table 1. The study patients consisted of 110 men and 90 women, and mean age of the patients was 53.4 years. Of the 200 total patients, 154 underwent subtotal gastrectomy, and 46 underwent total gastrectomy with more than D1+ lymph node dissection. The mean operating time for all patients was 248.8 minutes, and mean length of hospitalization was 8.0 days. Mean number of retrieved lymph nodes was 37.9. The final pathologic report revealed that 22 patients had cancers beyond stage II, and 31 patients showed lymph node metastasis. Resection margins were tumor-free in all patients (Table 2).
Demographics of the patients (n=200)
Surgical and pathologic outcomes
2. Postoperative complications
Twenty patients (10%) developed postoperative complications (Table 3). Half of them developed mild complications, such as wound problems, adhesive ileus, or delayed emptying, and 3 developed complications of moderate severity. All were successfully managed conservatively. Six patients had severe complications requiring invasive procedures, including 3 cases of reoperation: one duodenal stump repair, one hernia repair, and one open drainage for pancreatitis that did not respond to medical treatment. One mortality due to myocardial infarction occurred on postoperative day 2. No specific intraoperative events, such as bleeding or traumatic injury to normal organs, occurred.
Postoperative complications graded according to the Accordion severity classification (n=20)
3. Comparison of surgical outcomes between initial 100 and later 100 cases
Surgical outcomes of the initial 100 and later 100 cases were reviewed and compared (Table 4). Operating time was significantly shorter in the late surgery group as compared to that in the early cases (269.9±54.8 vs. 233.5±51.3 minutes, P<0.001). The number of retrieved lymph nodes was greater in the latter 100 cases, and this difference was statistically significant (35.9±13.0 vs. 39.9±13.4, P=0.032). Blood loss during surgery and the incidence of postoperative complications did not differ between the 2 groups. Duration of hospital stay was shorter in the latter than in the earlier 100 cases, but the difference was not statistically significant (P=0.092). Mean length of hospital stay after surgery in complicated cases was compared between the 2 groups (Fig. 1). Although the incidence and severity distribution were not different between the 2 groups, the median length of stay of 8 patients with complications in the initial 100 cases was significantly longer than that of 12 patients in the latter 100 cases (16 vs. 7 days, P=0.005, Mann-Whitney U test). Subgroup analysis according to surgical extent showed similar results (Table 5). Operating time was significantly decreased in the latter 100 cases, both in subtotal and total gastrectomy (P<0.001 and =0.003, respectively). The number of retrieved lymph nodes was greater in the latter 100 cases, both in subtotal and total gastrectomy, but the difference was not statistically significant (P=0.243 and 0.091, respectively).
Comparison of length of hospital stay between the initial and latter experience in complicated cases. Error bar depicts interquartile ranges (Mann-Whitney U test applied).
Comparison between early and late surgical experiences
Comparison of surgical outcomes according to the surgical extent
4. Relationship between operating time and accumulation of experience
Operating time gradually decreased along with the accumulation of surgical experience in 2 participating surgeons (Fig. 2). For one surgeon who only performed robotic surgery in 11 cases, no significant correlation to improved operating time could be demonstrated. Operating time during subtotal gastrectomy was inversely related to the number of robotic surgeries performed and revealed statistical significance in both surgeon I and II (P<0.001 and P=0.037, respectively). Likewise, a decreasing trend in operating time was seen during total gastrectomy, but the relationship was statistically significant only in surgeon I (P=0.039).
Change in operating time. Operating time gradually decreased along with the accumulation of surgical experience. (A) Robot-assisted distal gastrectomy, (B) Robot-assisted total gastrectomy.
Robotic gastrectomy is reported to be increasingly performed in Korea over the last 7 years.12 Nonetheless, evidence for the effectiveness of robotic surgery for gastric cancer is limited. Only several case series have been published so far, mostly by Eastern Asian centers,1,13-16 and prospectively randomized controlled trials (RCTs) reporting on safety and feasibility have not yet been published.12 By contrast, the value, safety, and feasibility of laparoscopic surgery for early gastric cancer has been proven in several RCTs.2,3,5,17 Robotic surgery is assumed to improve short-term patient outcomes such as length of postoperative hospital stay, frequency of postoperative complications, and quality of life.12 However, all previous studies have failed to demonstrate the superiority of robotic surgery as compared to the laparoscopic approach. Our previous study revealed that surgical trauma in terms of cytokine response was not reduced in robotic surgery patients as compared with laparoscopically resected patients.18
The main focus of our analysis was to see whether increasing experience with robotic gastrectomy could improve the quality of surgery after the known learning curve of 20 initial cases.19 We found that gaining experience with the robotic procedure translated into improved outcomes, especially in terms of operating time and number of dissected lymph nodes.
Mean operating time in our cohort was approximately 250 minutes, with a statistically significant decrease of operating time within the analyzed period. The first 100 cases had a mean operating time of around 270 minutes compared to approximately 230 minutes for the second 100 cases. Operating times in previously published series range from 150 to 700 minutes, depending on the type of resection.1,6-8,13-17,20-24 Interestingly, there appears to be a relationship between caseload and operating time. Institutions with low caseloads seem to take longer for the robotic procedure compared to the time taken by those with high caseloads where surgeons presumably have more experience with minimally invasive laparoscopic surgery. Compared to various published studies, our study cohort was among those with the shortest operative time, especially after the first 100 cases. It remains elusive if shorter operative time results in a lower postoperative complication rate. The prevailing mode of reconstruction in our analysis was Billroth I, followed by Billroth II and Roux-en-Y anastomosis, according to the surgeon’s preference. We did not notice any difference in operating time related to reconstruction methods as all anastomoses were performed extracorporeally. Nonetheless, intra-abdominal robot-sewn anastomosis has been demonstrated to be safe and feasible14 and might contribute to reduction of postoperative trauma in the future.
Blood loss within our cohort lies within the range of other published series.1,6-8,13-17,20-24 We also found a marked reduction in blood loss within our cohort after the first 100 cases of surgical experience, but it was not statistically significant. Reviewing published data, blood loss was almost always reduced for robotic surgery patients as compared to laparoscopic or open surgery patients.1,6-8,20 It may be debatable if application of robotic surgery really influences operative trauma, and consequently blood loss, or if due to the retrospective aspect of the studies, a selection bias of patients prevailed. A selection bias may have been that only patients with clinical stage IA cancer were selected for robotic surgery and limited lymphadenectomy was performed. Nonetheless, blood loss improved as patient numbers increased, so a learning curve is likely.25
We report a postoperative complication rate of 10%, which compared to previously published studies, is acceptable. European studies reported postoperative complication rates of up to 46%20,21,23 whereas Asian studies demonstrate postoperative complication rates of 10% to 15%.1,6-8,13-15,22,24 The high complication rates from European publications may be explained by the relatively lower caseload due to reduced gastric cancer incidence. It is also conceivable that less experience in minimally invasive (laparoscopic) surgery for gastric cancer may explain the higher European complication rates. The classification of complication might have been different as well, especially when the Accordion Severity Grading System was applied.10 Nonetheless, postoperative stay in the present study is among the shortest compared to other published studies. This might be, in part, due to the low postoperative morbidity rate of 10%. Furthermore, the median length of hospital stay for complicated patients was markedly decreased in the later 100 cases. This suggests that surgical outcomes regarding the severity of postoperative complications improve with the accumulation of experience in robotic gastrectomy.
A crucial aspect of curative resection for gastric cancer patients is adequate lymphadenectomy. We found an increased number of dissected lymph nodes in the second 100 patients. Therefore, we believe that lymph node retrieval improves with increasing experience with the robotic procedure. Although the benefit of lymph node dissection in gastric cancer treatment is still controversial in Europe,26,27 improved lymph node retrieval could be an advantage of robot-assisted surgery. The 3-dimensional and other enhanced imaging techniques used in robotic surgery to identify lymph nodes may contribute to an improved oncologic outcome for patients.15 Within our patient cohort, a mean number of 38 lymph nodes were dissected, indicating appropriate lymphadenectomy as compared to previously published papers.1,6-8,13-17,20-24 Interestingly, European case series reveal lower numbers of resected nodes compared to Asian reports, suggesting that traditional experience with D2 dissection translates into successful application of the robotic procedure. When robot-assisted resection was compared to laparoscopic resection in previous reports, there was no inferiority of lymph node retrieval for the robotic procedure, indicating that adequate lymphadenectomy is safe and feasible in robotic gastrectomy.6-8,24
The present study has several limitations. It was based on a retrospective analysis, which could have led to a selection bias. One of the participating surgeons contributed only 11 cases out of 200, and his experience gained might be questionable. The surgical outcomes were not properly stratified according to the additional combined surgical procedures, such as cholecystectomy or splenectomy.
In conclusion, we found that increased experience with the robotic procedure for gastric cancer surgery translated into improved outcomes, especially in operating time and number of dissected lymph nodes. Prospective trials will have to focus on patient benefit and outcome. Improvements in lymphadenectomy may be conceivable due to the technical advantages of the robotic device compared to laparoscopic procedures
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Articolo di Roberto Esposito “L’arte del dubbio” (Repubblica 22.2.15)
“”In principio fu Socrate. Poi toccò a Sant’Agostino e ancora a Cartesio, alla modernità e a Kant. Eppure ci voleva l’era della confusione digitale e dell’overdose continua di informazioni per farci capire che solo l’assenza di certezze può aiutarci a restare liberi
NEL cercare Dio in tutte le cose resta sempre una zona di incertezza. Le grandi guide del popolo, come Mosè, hanno sempre lasciato spazio al dubbio». A pronunciare tali parole non è un filosofo neoscettico, ma papa Francesco nella sua prima intervista a Civiltà Cattolica . In molti hanno visto in esse, più che una semplice apertura all’esigenza di rinnovare il linguaggio della Chiesa, la testimonianza del ruolo crescente che la dimensione del dubbio ha assunto nella nostra società. In questo senso il grande successo che sta riscontrando in Francia, anche a livello di partecipazione ai corsi universitari, la “zetetica” — come Henri Broch ha definito l’arte del dubbio nei confronti di settarismi, faziosità, dogmi ammantati di pretese scientifiche — non può sorprendere: viviamo immersi un un’epoca in cui ci arriva continuamente una massa enorme di informazioni. E così il controllo sulla autenticità, sulla buona fede, sulla correttezza o sulla logica interna di qualsiasi messaggio, dal tweet di un personaggio noto a un documento ufficiale di un’istituzione, diventa un’attività cruciale, un meccanismo di sopravvivenza: l’unico esercizio possibile per non restare impigliati nelle miriadi di reti della propaganda presenti su internet così come nei prodotti culturali più tradizionali, nella politica così come nelle discipline accademiche, nei video degli estremisti islamici così come nelle verità di regime di ogni luogo e tempo.
È chiaro che, in questo contesto, l’arte del dubbio cambia pelle. Da perno di sistemi di pensiero illuministi o liberal di vario spessore, diventa adesso quello che in fondo è sempre stata: un metodo di conoscenza, un approccio da applicare in maniera trasversale in qualsiasi campo della nostra vita. Una guida indispensabile in un mondo globalizzato, spezzettato, confuso eppure sempre a rischio di finire intrappolato nelle spire del pensiero unico di turno.
Per queste sue caratteristiche, il rilievo filosofico del dubbio naturalmente è antico — può essere fatto risalire alla classica formula socratica del “sapere di non sapere”. Teorizzato dal Pirrone già nel III secolo avanti Cristo, ha trovato una prima formulazione cristiana, condizionata alla verità divina, con sant’Agostino. Successivamente Descartes lo ha posto alla base della conoscenza: pur dubitando di tutto, non si potrà mai dubitare di essere, proprio perciò, un soggetto pensante. Se Pascal e Hume hanno diversamente sottoposto l’idea di certezza assoluta a una critica corrosiva, è stato Kant ad assumere a oggetto di dubbio la ragione stessa, individuandone possibilità e limiti. Tutta la discussione novecentesca sulla relazione indissolubile tra dubbio e certezza — sostenuta da Wittgenstein, ma anche, diversamente, da Popper, Kuhn, Lakatos — ha insistito sulla necessaria falsificabilità dei paradigmi scientifici.
D’altra parte se Kierkegaard scrive in Aut Aut che il dubbio appartiene al movimento interno del pensiero, nel suo Zibaldone Leopardi afferma che «piccolissimo è quello spirito che non è capace o è difficile al dubbio». Su questa linea di ragionamento, che desume la necessità di dubitare dal carattere finito e incompiuto del nostro sapere, Vladimir Jankélévitch, in Da qualche parte nell’incompiuto ( Einaudi, a cura di Enrica Lisciani Petrini), sostiene che, contro le false certezze, va tenuto fermo «il dubbio rispetto alle verità e a se stessi». E tuttavia fin qui non siamo ancora pervenuti al cuore del problema. Perché qualcosa che appartiene alla storia dell’intera tradizione filosofica torna oggi a interpellarci con particolare urgenza? Cosa rende la richiesta all’arte del dubbio così pressante?
Già alla fine degli anni Settanta un volume collettivo curato da Aldo Gargani, con il titolo Crisi della ragione ( Einaudi), monopolizzò il dibattito filosofico in concomitanza con il successo internazionale del libro sul postmoderno di Jean-François Lyotard (Feltrinelli). Ciò che in quegli anni pareva incrinarsi era un intero regime di senso che per un lungo periodo aveva costituito al contempo la struttura indubitabile del reale e un modello normativo di comportamento. A venire meno era il primato del passato sul presente — l’idea che tutto ciò che avveniva fosse predeterminato da quanto lo precedeva secondo un nesso diretto tra cause ed effetti. Quando invece ai codici razionali si accompagnano sempre elementi imprevedibili di tipo intuitivo, emotivo o pragmatico, spesso portati a configgere con essi.
Ma una scossa ancora più destabilizzante si è verificata negli ultimi anni, quando, con il nuovo disordine globale, tutti i riferimenti che fino a qualche tempo fa hanno guidato i nostri comportamenti sembrano essere venuti meno. Da qui nasce la spinta a una ricerca ininterrotta, capace di sfidare dogmi e luoghi comuni. Il termine stesso di zetetica rimanda al verbo greco che significa “cercare”. Alla sua base vi è un bisogno urgente di spirito critico, una diffidenza crescente rispetto alla continua manipolazione che media spregiudicati o asserviti, sondaggi con esiti preconfezionati, dispositivi di propaganda ci rovesciano quotidianamente addosso.
Gli attentati di Parigi, rivolti espressamente contro la libertà di pensiero e di scrittura, hanno rinforzato ulteriormente questa esigenza, come dimostra la pronta scalata delle opere di Voltaire nella zona alta delle classifiche di vendita. Già preparata dal successo di instancabili partigiani del dubbio come Montaigne e Diderot, il ritorno, non solo da parte dei francesi, a Voltaire rilancia la tradizione dei lumi contro l’accecamento prodotto dal fanatismo. Tale impulso zetetico, d’altra parte, si innesta in un orizzonte filosofico già orientato in direzione laica e libertaria. Esso rimanda a filoni culturali diversi, che hanno trovato un primo punto di aggregazione nel “New Atheism” americano — teorizzato da filosofi e saggisti come Richard Dawkins, Daniel Dennet, Sam Harris e Christopher Hitchens. Ciò che li collega in uno stesso punto di vista non è la polemica contro particolari religioni, ma contro qualsiasi tipo di presupposto dogmatico che vincoli la ricerca scientifica e anche i comportamenti pratici. Si tratta di una interpretazione radicale del darwinismo, che sottrae il fenomeno della vita al rimando a qualcosa che ne trascenda lo sviluppo specifico.
A questa corrente — che dall’America si è diffusa in Germania, in Francia, in Italia — si affiancano altri filoni libertari ispirati in vario modo alla tradizione illuministica. Il neo-materialismo individualista di Michel Onfray, autore di un discusso Trattato di ateologia ( tradotto in Italia da Fazi), è stato oggetto di un ampio dibattito e anche di forti critiche. Portando agli esiti estremi la dottrina della tolleranza che ha i suoi padri in Locke e nello stesso Voltaire, la sua prospettiva è caratterizzata da una critica preventiva di qualsiasi nozione che non sia passata al vaglio dell’analisi razionale. L’altra scuola di pensiero che, forse con maggiore consapevolezza teoretica, rompe con ogni forma di trascendenza è quella che guarda da un lato al pensiero di Spinoza e dall’altro alla genealogia di Nietzsche. Ciò spiega la forte ripresa di interesse per un autore come Gilles Deleuze, del quale DeriveApprodi ha appena edito il film-intervista, a cura di Claire Parnet, dal titolo Abecedario. Forse prevedendo la svolta in atto, Michel Foucault aveva una volta pronosticato «che un giorno il secolo sarà deleuziano». Prudentemente non aveva specificato di quale secolo parlava.